LRRTM1 leucine rich repeat transmembrane neuronal 1 [ (human)]. Gene ID: , updated on 7-Dec This gene is imprinted, being predominantly expressed from the paternal allele and showing a variable pattern of maternal down-regulation. May be associated . Leucine-rich repeat transmembrane neuronal protein 1. Gene. Lrrtm1. Organism. Mus musculus (Mouse). Status. Reviewed-Annotation score: Annotation.
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March 6, Last modified: However, it is also possible that the failure to replicate the association with handedness was lrrtj1 to low power and a relatively small replication sample in our study.
Leucine-rich repeat transmembrane neuronal protein 1
OMIM is intended for use primarily by physicians and other professionals concerned with genetic disorders, by genetics researchers, and by advanced students in science and medicine. We carried out SNP-based association screening for human relative hand skill, under a parent-of-origin model, within four candidate genes close to or within 6 mb of a peak of paternal-specific linkage on 2p12, in a sample of sib pairs recruited for the presence of RD.
We found that human LRRTM1 is imprinted paternal-only expression in hybrid A9 cells 24 mouse cell lines containing single human chromosomes of known parental origin Figure 2. Protein Spotlight The hands to say it – Issue 91 of February National Institutes of Health. We also tested for association in a sample of Han Chinese families 23 but we found no significant bias in paternal or maternal transmission gdne any haplotype to schizophrenic people there were 65 gehe transmissions to 78 paternal nontransmissions of the haplotype.
Reactome – a knowledgebase of biological pathways and processes More In a recent ,rrtm1 of 20 linkage screens for schizophrenia, 2p12—q22 was the only location to reach significance when adjusted for genome-wide testing. The molecular, developmental and evolutionary origins of human brain asymmetry are unknown. Of a total of approximately 35 human genes, only roughly 40 were previously known to be imprinted, and the total number is unlikely to exceed this greatly.
LRRTM1 – leucine rich repeat transmembrane neuronal 1
A lrttm1 that provides location information. UCSC genome browser More TreeFam database of animal gene trees More Asymmetry of fetal cerebral hemispheres: The rsrsrs haplotype where 2 is the minor allele of each SNP was responsible primarily for the paternal-specific association observed with haplotypes derived from these three SNPs.
This page was last edited on 30 Octoberat Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Heritability of lobar brain volumes in twins supports genetic models of cerebral laterality and handedness.
In situ hybridization of adult mouse brain detected widespread Lrrtm1 expression predominantly in neurons. This entry has llrrtm1 described isoform and 1 potential isoform that is computationally mapped.
In coronal sections of anterior brain aexpression genne strong throughout the cortical plate and otherwise restricted to septum, caudate, and putamen. Orthologs of LRRTM1 were detected in databases derived from several vertebrate species but not in databases derived from Drosophila or C. Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry.
Assessing the frequency of this gnee will require studies in further clinical and epidemiological samples, together with a better definition of the functional genetic and epigenetic variation at the LRRTM1 locus.
Expression is upregulated in the mouse brain during embryonic development lrtm1 early postnatally. In addition, expression within the human thalamus was more restricted as compared to the mouse, with staining relatively limited to dorsomedial regions.
SwissPalm database of S-palmitoylation events More June 21, Last sequence update: May be associated paternally with handedness and schizophrenia.
RCSB PDB – Gene View – LRRTM1 – leucine rich repeat transmembrane neuronal 1
No cell-surface expression of LRRTM1 is seen in primary sensory neurons electroporated with myc-LRRTM1 construct and detected by live-cell staining with alkaline phosphatase-conjugated anti-myc antibody a ; strong cell-surface staining of myc-Lingo1 expressing neuron is seen b. Handedness, brain asymmetry and schizophrenia are likely to be etiologically complex traits with several, or many, rlrtm1 and environmental influences.
UniGene gene-oriented nucleotide sequence clusters More At 10 and 11 dpc expression is restricted to the egne ectodermal ridge.